Shared and distinct antispastic effects of electrical and pharmacological neuromodulation
Key Information
This research study wants to learn if electrical stimulation can reduce muscle stiffness and spasms in people with spinal cord injury. For this, we will place stimulation pads on the lower back and the belly to activate nerves near the spinal cord. This type of electrical stimulation is known as transcutaneous spinal stimulation. In general, the side effects of electrical stimulation are mild and short-lasting; however, the stimulation for 30 minutes may be uncomfortable.
In addition, you will be asked to take a single dose of an antispastic drug or placebo to compare the effect of electrical stimulation to routine treatments. Antispastic drugs have commonly reported side effects: dizziness, drowsiness, dry mouth, fatigue, hypotension, slowing heart rate, and weakness.
You will be asked to come to the Methodist Rehabilitation Center in Jackson, Mississippi six times. Each visit will take about 4 hours to complete the tests with electrical stimulation intervention. Your participation in the study will be 3 to 5 weeks.
Eligibility Criteria
- Age 18 years or older
- History of spinal cord injury (ASIA Impairment Scale grades A-D)
- Time since injury longer than six months
- The presence of at least mild spasticity
More information
Contact Jennifer Sivak, OTR/L
Research Occupational Therapist
Phone: (601) 364-3567
Email: jsivak@mmrcrehab.org.